Recent advances in our understanding of tuberculosis infection demonstrate that infection within a given individual is highly heterogeneous; however, the determinants that drive lesions towards complete bacterial sterilization remain poorly understood. We are interested in developing new tools to dissect the complex dynamics of bacterial infection at a variety of scales ranging from single cells to infected hosts sitting in both “reference frames” by taking both an immunologist’s and a microbiologist’s perspective. Combining new technologies with classical approaches, we are focused ultimately on the goal to manipulate the immune system to improve bacterial control.
Our research revolves around two motivating questions –
To this end, we are pursuing several projects aimed at both answering these question directly and developing new tools to further our understanding of these complex bacterium